Covalentlab is an interactive, design-driven platform for rational covalent drug design, enabling the identification of nucleophilic residues in ligand-binding sites, selection of optimal covalent warhead attachment points, and integration of warheads into ligands. It supports nine types of amino acid targets and a curated library of 220 warheads, generating a comprehensive database of 34,567 covalent molecules across 100 targets and 50 diseases. Covalentlab allows users to search and design covalent inhibitors efficiently, expanding the chemical space and facilitating drug discovery across various therapeutic areas.